I just finished reading this book. In summary, Dr. Bredesen says that Alzheimer’s is due to three main category of insults.
- Inflammation
- Brain nutrient deficiencies
- Toxicity
Amyloid beta is produced by cleavage into 4 pieces (bad) or 2 pieces (good). When there is too much of the above insults, amyloid beta is produced in the bad 4 pieces form as a protective mechanism.
Alzheimer’s is a multi-factor disease. He says there are about 36 markers we have to optimize for. I tried to find a list of the 36, but came up with this chart from his paper. Apoe4.info also has a summary of Bredesen protocol.
Watch interviews of Dr. Bredesen on YouTube here.